MABE1795-100UL | Anti-PP4C Antibody, clone 7B5

新着MABE1795-100UL
100 µL  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE1795-100UL
      DescriptionAnti-PP4C Antibody, clone 7B5
      Alternate Names
      • Serine/threonine-protein phosphatase 4 catalytic subunit
      • EC: 3.1.3.16
      • Pp4
      • PPP4C
      • Protein phosphatase X
      • PP-X
      Background InformationSerine/threonine-protein phosphatase 4 catalytic subunit (UniProt: P60510; also known as EC: 3.1.3.16, PP4C, Pp4, Protein phosphatase X, PP-X) is encoded by the PPP4C (also known as PPP4, PPX) gene (Gene ID: 5531) in human. Protein phosphatase 4 (PP4), a ubiquitous serine/threonine phosphatase, is involved in the regulation of many cellular processes. It functions independently of protein phosphatase 2A (PP2A). Mammalian PP4 contains two regulatory subunits (R1 and R2) that interact with the catalytic subunit (PP4C)) and control its activity. Methylation at the C-terminal Leucine 307 is critical for interactions with regulatory subunits. PP4C-R2 complexes are reported to be involved in organelle assembly, maturation of the centrosome, apoptosis, DNA repair, and spliceosomal assembly. It is also reported to play a role in cell migration and in activation of c-Jun N-terminal kinase and NF-kappa B. PP4C has multiple metal ion binding sites and can bind two manganese ions per subunit. (Ref.: Cohen, PTW., et al. (2005). FEBS Lett. 579(15); 3278-3286).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PP4C, clone 7B5, Cat. No. MABE1795, is a highly specific mouse monoclonal antibody that targets Serine/threonine-protein phosphatase 4 catalytic subunit and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected PP4C in lysate from NIH3T3 mouse fibroblasts ectopically expressing N-terminally tagged human PP4 catalytic subunit (PPP4C).(Courtesy of Dr. Stefan Schuechner and Dr. Egon Ogris, Medical University of Vienna, Austria).
      Biological Information
      ImmunogenKLH-conjugated linear peptide coreesponding to 17 amino acids from the C-terminal region of human Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C).
      Clone7B5
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7B5 specifically detects human Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C). It targets an epitope within 17 amino acids from the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat, Rabbit, Bovine based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPP4C
      • PPP4
      • PPX
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight35.08 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceIsotype testing: Identity Confirmation by Isotyping Test.

      Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG1.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications