SMB01318
3-Hydroxydesloratadine
別名:
3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
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この商品について
実験式（ヒル表記法）:
C19H19ClN2O
CAS番号:
分子量:
326.82
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90%
Form:
solid
description
Modulation and Signaling
Quality Segment
assay
≥90%
form
solid
technique(s)
HPLC: suitable
color
pale yellow to off-white
storage temp.
−20°C
SMILES string
Clc1cc2c(cc1)C(=C4CCNCC4)c3ncc(cc3CC2)O
InChI
1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
InChI key
NDFMTPISBHBIKE-UHFFFAOYSA-N
General description
3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.
Application
3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research
Biochem/physiol Actions
3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with a wide variety of chromatographic and spectrometry techniques
Other Notes
For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SMB01318-10MG: + SMB01318-1MG: + SMB01318-BULK: + SMB01318-VAR:
jan