440191
Hexaméthyldisilazane
reagent grade, ≥99%
Synonyme(s) :
HMDS
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A propos de cet article
Formule linéaire :
(CH3)3SiNHSi(CH3)3
Numéro CAS:
Poids moléculaire :
161.39
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
213-668-5
Beilstein/REAXYS Number:
635752
MDL number:
Service technique
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reagent grade
Quality Segment
assay
≥99%
form
liquid
refractive index
n20/D 1.407 (lit.)
bp
125 °C (lit.)
SMILES string
C[Si](C)(C)N[Si](C)(C)C
InChI
1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
InChI key
FFUAGWLWBBFQJT-UHFFFAOYSA-N
General description
Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.
Application
Hexamethyldisilane (HMDS) can be used:
- As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
- To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
- To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
- For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.
Features and Benefits
- High chemicalstability and low molecular weight
- Nontoxic andcost-effective reagent
- Ammonia is theonly byproduct generated during silylation
- Silylationreaction using HDMS is nearly neutral and does not need any precaution
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Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
Classe de stockage
3 - Flammable liquids
wgk
WGK 2
flash_point_f
52.5 °F - closed cup
flash_point_c
11.4 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Rapid and highly efficient trimethylsilylation of alcohols and phenols
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
Eskandar K, et al.
Journal of Chemical Sciences (Bangalore), 123(5), 703-708 (2011)
F Braet et al.
Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS
Judith J de Vries et al.
International journal of molecular sciences, 21(19) (2020-10-01)
Subjects with diabetes mellitus (DM) have an increased risk of arterial thrombosis, to which changes in clot structure and mechanics may contribute. Another contributing factor might be an increased formation of neutrophil extracellular traps (NETs) in DM. NETs are mainly