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Merck

PHR1309

Dimethyl Sulfoxide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Sulfoxide, DMSO

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A propos de cet article

Numéro CAS:
67-68-5
UNSPSC Code:
41116107
EC Number:
200-664-3
NACRES:
NA.24

Principaux documents

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Nom du produit

Dimethyl Sulfoxide, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

[S](=O)(C)C

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. D2050000
traceable to USP 1211006

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Dimethyl Sulfoxide (DMSO) is an amphipathic molecule and contains both highly polar and apolar groups, making it an efficient solvent as it can dissolve in both aqueous and organic solvents. It has its therapeutic use in the treatment of a variety of human conditions such as brain edema, amyloidosis, interstitial cystitis, and schizophrenia. It is a commonly used solvent for hydrophobic pharmaceutical agents, exhibiting effective hydroxyl radical scavenging ability. Commercially it is produced by oxidation of dimethylsulfide (DMS) with dinitrogen tetroxide. It is a component of a wide variety of foodstuffs and beverages.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0526 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils
Phillis JW, et al.
Neuroscience Letters, 244(2), 109-111 (1998)
Farhana Musarrat et al.
Journal of medical virology, 92(10), 2087-2095 (2020-05-07)
Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is the causative agent of the coronavirus disease-2019 (COVID-19) pandemic. Coronaviruses enter cells via fusion of the viral envelope with the plasma membrane and/or via fusion of the viral envelope with endosomal membranes
Solvation and ion pairing of alkali-metal alkoxides in dimethyl sulfoxide. Conductometric studies
Exner JH and Steiner EC
Journal of the American Chemical Society, 96(6), 1782-1787 (1974)
Application of nuclear magnetic resonance spectroscopy for quantitative analysis of miconazole, metronidazole and sulfamethoxazole in pharmaceutical and urine samples
Salem AA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(2), 654-661 (2006)
Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations.
Kanaze FI, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33(2), 243-249 (2003)
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