RAB0978
Phosphotyrosine CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit
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NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... CSF1R(1436)
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
Servicio técnico
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Permítanos ayudarlespecies reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CSF1R(1436)
General description
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-MCSFR.
CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
CSF1R (colony stimulating factor 1 receptor) and its ligand CSF1 are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
Los componentes del kit también están disponibles por separado
Referencia del producto
Descripción
SDS & Precios
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Clase de almacenamiento
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function.
Pridans C, et al.
Scientific Reports, (3), 3013-3013 (2013)
Takuya Konno et al.
Neurology, 82(2), 139-148 (2013-12-18)
To clarify the genetic, clinicopathologic, and neuroimaging characteristics of patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS) with the colony stimulating factor 1 receptor (CSF-1R) mutation. We performed molecular genetic analysis of CSF-1R in patients with HDLS. Detailed clinical and
A Patsialou et al.
Oncogene, 34(21), 2721-2731 (2014-08-05)
Patient data suggest that colony-stimulating factor-1 (CSF1) and its receptor (CSF1R) have critical roles during breast cancer progression. We have previously shown that in human breast tumors expressing both CSF1 and CSF1R, invasion in vivo is dependent both on a