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Stem Cell Research Antibodies & Assays

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Ant-Fail We Know Antibodies

We Know Antibodies

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Stem cells have the unique ability to turn into different tissues of the body based on specific environmental cues exerted upon the cells. The identification of the key proteins involved in maintaining stem cell identity and functional have been critical to understand stem cell biology. Key transcription factors such as Oct-4, Nanog and Sox-2 are critical in maintaining embryonic and induced pluripotent stem cells in their pluripotent state. Upon differentiation, many of these pluripotency genes are downregualted while other differentiated markers are upregulated depending on the local environmental cues. Understanding what causes these changes is the key to understanding stem cell biology. Merck is committed to providing validated stem cell antibodies for common and novel protein targets which are related to all areas of stem cell biology. From pluripotent stem cells to neural and mesenchymal stem cells, antibodies exist in various formats for each target, validated in different research applications and cited in many publications.


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Featured Product:
Anti-Oct-4, clone 10H11.2
Featured general cell culture antibody
Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types.

Primary Stem Cell Antibodies

Merck offers a wide range of validated antibodies to many of the most commonly studied proteins in stem cell biology. Rely on the expertise of Chemicon and Upstate to advance your stem cell research today.

Oct-4 TRA Family
Sox Family SSEA Family
Wnt Family Nestin
Nanog Human Nuclei
Lin-28 Human Mitochondria

Stem Cell Antibody Conjugates

Merck offers stem cell conjugates for some of the most popular stem cell markers in various formats including AlexaFluor-488, CY3, FITC and PE conjugated antibodies. “FlowCellect” antibodies have been validated and are pre-diluted to work in flow cytometry applications. Other non “FlowCellect” antibody conjugates have been validated for Immunocytochemistry. All conjugates maintain their antigen specificities while eliminating the use of cumbersome secondary antibodies. Rely on the conjugated forms of these antibodies to collapse the experimental workflow and save time and money.

Anti-Nuclei Antibody Clone

Characterization Kits

Due to our vast stem cell antibody product offering, we have developed many characterization kits for commonly differentiated stem cell derivatives. These kits contain a collection of commonly assayed monoclonal and polyclonal antibodies which are routinely used to identify the cell type of interest. These kits are a reliable solution used to quantify the level of differentiation achieved in different types of stem cells. Characterization kits are available for pluripotent stem cells, cardiomyocytes, pancreatic cells, neural stem cells, mesenchymal stem cells and many other cell types.