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Cellular Reprogramming

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Featured Webinar
Understanding the Key Epigenetic Processes in Cellular Reprogramming and Pluripotency-Building Future Therapeutics

Featuring Andras Nagy, PhD (Shawn Kimel Scientist, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)

Featured Literature:
RNA Reprogramming Technology
Simplicon™ RNA Reprogramming Technology

Single Transfection. Virus-free iPSCs 
  • Create integration-free iPS cells using syntheticRNA
  • Reprogram efficiently and easily using a single transfection step
  • Achieve controlled elimination of reprogramming factors
Simplifying the iPSC Workflow Brochure
The discovery that somatic cells could revert back to pluripotent like cells (induced pluripotent stem cells) in 2006 by Shinya Yamanaka created an entirely new area of stem cell biology. IPS cells removed the ethical concerns associated with embryonic stem cells and allowed scientists to model human diseases that were previously impossible to model such as Alzheimer’s, Parkinson’s and autism. The current science of inducing pluripotency in cells has yielded practical technologies and protocols for a new generation of applied stem cell research. These innovations have advanced all steps of the reprogramming workflow: iPS cell generation; iPS cell culture; iPS cell characterization; and iPS cell differentiation. iPS cell clones must be carefully characterized before any application in diagnosis or therapy. Following characterization of ES-like state, the iPS cells can be guided down distinct differentiation pathways using various growth factors, small molecules, or other extracellular microenvironment manipulations. 

Merck is dedicated to developing and refining these induced pluripotent stem (iPS) cell technologies. With Merck’s comprehensive portfolio of reagents and antibodies, including the expertise of Upstate®, Chemicon, and Calbiochem brands, researchers now have reliable, high-quality solutions for cellular reprogramming.