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700001P

Avanti

DC-Cholesterol HCl

Avanti Research™ - A Croda Brand

Synonyme(s) :

3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C32H57N2O2Cl
Numéro CAS:
166023-21-8
Poids moléculaire :
537.26
UNSPSC Code:
12352211
NACRES:
NA.25
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Nom du produit

DC-Cholesterol HCl, Avanti Research™ - A Croda Brand 700001P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700001P-1g), pkg of 1 × 200 mg (700001P-200mg), pkg of 1 × 25 mg (700001P-25mg), pkg of 1 × 500 mg (700001P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700001P

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]

InChI

1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H

InChI key

ISXSJGHXHUZXNF-UHFFFAOYSA-N

General description

DC-Cholesterol HCl is a sterol-based transfection reagent.
DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid with a head group and linker moiety.

Application

DC-Cholesterol HCl is suitable:
  • for the preparation of ultrasound cationic microbubbles
  • to prepare liposomes
  • for the preparation of L-glutathione (GSH), loaded proliposomes

DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies. It may also be used in liposome preparation for assessing hexokinase activity, poly (lactic-coglycolicacid) loading and in mRNA transfection studies.

Biochem/physiol Actions

DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).
DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.

Packaging

20 mL Clear Glass Screw Cap Vial (700001P-1g)
20 mL Clear Glass Screw Cap Vial (700001P-500mg)
5 mL Amber Glass Screw Cap Vial (700001P-200mg)
5 mL Amber Glass Screw Cap Vial (700001P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Consulter la Bibliothèque de documents

Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability
Byeon JC, et al.
Drug delivery, 26(1), 216?225-216?225 (2019)
PLGA/liposome hybrid nanoparticles for short-chain ceramide delivery
Zou P, et al.
Pharmaceutical Research, 31(3), 684-693 (2014)
Cationic liposome (DC-Chol/DOPE= 1: 2) and a modified ethanol injection method to prepare liposomes, increased gene expression
Maitani Y, et al
International Journal of Pharmaceutics, 342(1-2), 33-39 (2007)
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