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EPS002

MS-275

Name: MS-275
Brand: SIGMA

A HDAC1 and HDAC3 inhibitor

Synonyme(s) :

MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₁H₂₀N₄O₃

Numéro CAS:

209783-80-2

Poids moléculaire :

376.41

NACRES:

NA.41

PubChem Substance ID:

329799578

UNSPSC Code:

12352200

MDL number:

MFCD03453552

Assay:

≥99%

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Propriétés

assay

≥99%

solubility

DMSO: 38 mg/mL

storage temp.

−20°C

SMILES string

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChI key

INVTYAOGFAGBOE-UHFFFAOYSA-N

Gene Information

human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

Description

General description

Preferentially inhibits HDAC1 (IC₅₀=300 nM) over HDAC3 (IC₅₀=8 μM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 μM).

Application

MS-275 has been used as a histone deacetylase-1 inhibitor.

Biochem/physiol Actions

HDAC inhibitor; antiproliferative.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H360

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

7F25L15900

7E06L15900

4K011590

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Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation.

Marta Bombardo et al.

Scientific reports, 8(1), 9391-9391 (2018-06-22)

Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely regenerate the injured tissue or

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

TingDong Y et al.

Nature Communications, 100 (2018)

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.

Heather MacTavish et al.

PloS one, 5(12), e14462-e14462 (2011-02-02)

Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the

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