L9664
ロラタジン
≥98% (HPLC), Histamine H1 receptor antagonist, powder
別名:
4-(8-クロロ-5,6-ジヒドロ-11H-ベンゾ[5,6]シクロヘプタ[1,2-b]ピリジン-11-イリデン-1-ピペリジンカルボン酸エチルエステル, ロラチジン
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この商品について
実験式（ヒル表記法）:
C22H23N2O2Cl
CAS番号:
分子量:
382.88
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
製品名
ロラタジン, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: soluble 50 mg/mL, H2O: insoluble
originator
Schering Plough
storage temp.
2-8°C
SMILES string
CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI
1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key
JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information
human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)
rat ... Hrh1(24448)
Biochem/physiol Actions
非鎮静性のヒスタミンH1-レセプタ-アンタゴニストです。
Loratadine is a non-sedating histamine H1-receptor antagonist. Shown to inhibit the two-pore domain potassium channel K2P18.1 (also called TRESK or KCNK18).
Features and Benefits
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)