Skip to Content
Merck

810207X

Avanti

NBD Sphingosine-1-Phosphate

Avanti Research™ - A Croda Brand

Synonym(s):

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine-1-phosphate:methanol:water (65:25:4)

Sign In to View Organizational & Contract Pricing.

Select a Size

All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C24H40N5O8P
CAS Number:
799268-48-7
Molecular Weight:
557.58
MDL number:
MFCD00036835
NACRES:
NA.25
UNSPSC Code:
12352211

Product Name

NBD Sphingosine-1-Phosphate, Avanti Research™ - A Croda Brand 810207X

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810207X-100ug)
pkg of 1 × 1 mL (810207X-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810207X

concentration

0.05 mg/mL (810207X-50ug)
0.1 mg/mL (810207X-100ug)

shipped in

dry ice

storage temp.

−20°C

Related Categories

Application

NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.

Biochem/physiol Actions

Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.

General description

Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.

Packaging

5 mL Amber Glass Screw Cap Vial (810207X-100ug)
5 mL Amber Glass Screw Cap Vial (810207X-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Ito K, et al.
Biochemical and biophysical research communications, 357(1), 212-217 (2007)
Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
Hakogi T, et al.
Bioorganic & Medicinal Chemistry Letters, 13(4), 661-664 (2003)
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
Serra M and Saba JD
Advances in Enzyme Regulation, 50(1), 349-362 (2010)
Sphingosine-1-phosphate phosphatase 2 regulates pancreatic islet beta-cell endoplasmic reticulum stress and proliferation
Taguchi Y, et al.
The Journal of Biological Chemistry, 291(23), 12029-12038 (2016)
Gaelen S Smith et al.
Biomolecules, 3(3), 351-368 (2014-03-13)
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration. S1P functions as a trophic factor for many cell types, including embryonic stem cells (ESCs). Sphingosine

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service