Anti-BMAL1 Antibody

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

~70 kDa

KLH conjugated synthetic linear peptide corresponding to the internal domain of BMAL1.

This Anti-BMAL1 Antibody is validated for use in WB for the detection of BMAL1.

Cat. # AB2298 recognizes the internal domain of BMAL1.

Reactivity with other species has not been determined.

Format: Purified

Purified rabbit polyclonal antibody in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Control
HeLa nuclear extract tissue lysate.

Western Blot: 1:5000 dilution detected BMAL1 on 10 μg of HeLa nuclear extract.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.