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Key Documents

AB2299

Sigma-Aldrich

Anti-NR2E3 Antibody

from rabbit

Synonym(s):

Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor, nuclear receptor subfamily 2, group E, member 3, photoreceptor-specific nuclear receptor

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702

biological source

rabbit

antibody product type

primary antibodies

clone

polyclonal

species reactivity

bovine

species reactivity (predicted by homology)

mouse, human, rat

technique(s)

western blot: suitable

UniProt accession no.

Q9Y5X4

shipped in

wet ice

General description

NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
~44 kDa

Immunogen

Epitope: Full Length Protein

Application

Anti-NR2E3 Antibody is an antibody against NR2E3 for use in WB.

Biochem/physiol Actions

Cat. # AB2299 recognizes NR2E3 protein.
Reactivity with other species has not been determined.

Physical form

Format: Purified
Purified by GST-depletion followed by Protein A

Analysis Note

Control
Bovine Retina tissue lysate.
Western Blot:

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N Zabouri et al.
The Journal of comparative neurology, 519(7), 1258-1280 (2011-04-01)
Cannabinoid receptor type 1 (CB1R) participates in developmental processes in the central nervous system (CNS). The rodent retina represents an interesting and valuable model for studying CNS development, because it contains well-identified cell types with clearly established and distinct developmental
Sarah Naessens et al.
Genes, 10(5) (2019-05-15)
The recurrent missense variant in Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3), c.166G>A, p.(Gly56Arg) or G56R, underlies 1%-2% of cases with autosomal dominant retinitis pigmentosa (adRP), a frequent, genetically heterogeneous inherited retinal disease (IRD). The mutant NR2E3 protein

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