Key Documents
AB5028
Anti-Endorphin β Antibody
Chemicon®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
radioimmunoassay: suitable
suitability
not suitable for immunohistochemistry (Paraffin)
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Gene Information
human ... POMC(5443)
Immunogen
Synthetic peptide (H-Thy-Gly-Gly-Phe-Met-Thr-Ser-Lys-
Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-
Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH) from human beta-endorphin conjugated to thyroglobulin.
Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-
Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH) from human beta-endorphin conjugated to thyroglobulin.
Application
Anti-Endorphin Antibody, β is an antibody against Endorphin for use in IH, RIA.
Immunohistochemistry: 1:500-1:1,000 using immunofluorescence and 1:5,000-1:10,000 for indirect avidin-biotin.
Not recommended for traditional formalin fixed paraffin tissues. 4% formalin fixed, resin embedded tissues can be used. Antibodies should be diluted in simple solutions (PBS plus 1% BSA) only. Blocking should not contain serum.
RIA: 1:10,000; sensitivity 120 pg/sample; IC50 - 1 ng/sample)
Optimal working dilutions must be determined by the end user.
Not recommended for traditional formalin fixed paraffin tissues. 4% formalin fixed, resin embedded tissues can be used. Antibodies should be diluted in simple solutions (PBS plus 1% BSA) only. Blocking should not contain serum.
RIA: 1:10,000; sensitivity 120 pg/sample; IC50 - 1 ng/sample)
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Hormones & Receptors
Neuroinflammation & Pain
Hormones & Receptors
Biochem/physiol Actions
Beta-endorphin. Cross reactivity: Met-enkephalin 0.03%, Leu-enkephalin 0.02% and beta-Lipotropin 0.34%.
Physical form
Format: Purified
Purified immunoglobulin Liquid. Contains 0.1% sodium azide as a preservative.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
Other Notes
Replaces: CBL98
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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W Tongjaroenbuangam et al.
The European journal of neuroscience, 24(7), 1987-1994 (2006-10-17)
The inferior colliculus is a critical structure for processing auditory information and receives ascending and descending synaptic auditory projections. In addition to GABAergic and glutamatergic innervations, other neurotransmitter systems are also reported in the inferior colliculus, including opioid peptides. In
Peter Kirwan et al.
Molecular metabolism, 17, 82-97 (2018-09-12)
The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POMC processing between humans and rodents, and little is known
Jonna M Leyrer-Jackson et al.
Brain research, 1786, 147901-147901 (2022-04-04)
The endogenous opioid system has been implicated in the rewarding and reinforcing effects of alcohol. Pro-opiomelanocortin (POMC) neurons located within the arcuate nucleus of the hypothalamus (ArcN) secrete multiple peptides associated with alcohol consumption, including β-endorphin (β-END), α-melanocyte stimulating hormone
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