MAB2013
Anti-K-Cadherin Antibody, extracellular domain, clone 2B6
clone 2B6, Chemicon®, from mouse
Synonym(s):
Cadherin-6
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
biological source
mouse
Quality Level
antibody product type
primary antibodies
clone
2B6, monoclonal
species reactivity
human, rat
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... CDH6(1004)
General description
Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
Immunogen
Affinity purified extracellular domain of human K-cadherin
Epitope: extracellular domain
Application
Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 detects level of K-Cadherin & has been published & validated for use in WB, IC, IH.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Western blot: 1:25 - 1:250
Immunohistochemistry: 1:25 - 1:50; Frozen tissue sections with avidin-biotinylated horseradish peroxidase complex (ABC) as the detection method.
Optimal working dilutions must be determined by the end user.I/
Immunohistochemistry: 1:25 - 1:50; Frozen tissue sections with avidin-biotinylated horseradish peroxidase complex (ABC) as the detection method.
Optimal working dilutions must be determined by the end user.I/
Biochem/physiol Actions
Reacts with the extracellular domain of K-cadherin.
Physical form
Format: Purified
Purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide.
Preparation Note
1 year at 4°C from date of shipment
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
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