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Key Documents

MABE569

Sigma-Aldrich

Anti-CK1, clone 3C10F7 Antibody

ascites fluid, clone 3C10F7, from mouse

Synonym(s):

Casein kinase I isoform alpha, CKI-alpha, CK1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

3C10F7, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable

UniProt accession no.

P48729

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CSNK1A1(1452)

General description

39 kDa calculated
Casein kinase I isoform alpha (CKI-alpha), also known as CK1, and encoded by the gene name CSNK1A1, is a member of the keratin family. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells.CK1 consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. CK1 is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.

Immunogen

Purified recombinant fragment of human CK1 expressed in E. Coli

Application

Anti-CK1, clone 3C10F7 Antibody detects level of CK1 & has been published & validated for use in CK1.

Analysis Note

Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected CK1 in human liver, colon carcinoma, lung carcinoma and esophagus tissues.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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