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Merck

MABN740

Anti-GABA-B receptor 2 Antibody, clone N81/37

clone N81/37, from mouse

Synonym(s):

GABA-B-R2, GABA-BR2, GABABR2, Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, Gb2, G-protein coupled receptor 51

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-GABA-B receptor 2 Antibody, clone N81/37, clone N81/37, from mouse

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

N81/37, monoclonal

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_113990

UniProt accession no.

O88871

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GABBR2(9568)

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GABA-B receptor 2 in 10 µg of rat brain tissue lysate.

Application

Anti-GABA-B receptor 2 Antibody, clone N81/37 is a highly specific mouse monoclonal antibody, that targets GABA B Receptor & has been tested in western blotting & IHC.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blotting Analysis: 2.0 µg/mL from a representative lot detected GABA-B receptor 2 in 10 µg of mouse brain tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GABA-B receptor 2 in human cerebellum and rat cerebral cortex tissue.

Biochem/physiol Actions

This antibody does not cross react with GABABR1 (Prof. J. Trimmer, University of California, Davis).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
~105 kDa observed

Immunogen

Recombinant protein corresponding to rat GABA-B receptor 2.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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