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OP19

Sigma-Aldrich

Anti-c-Abl (Ab-2) Mouse mAb (19-110)

liquid, clone 19-110, Calbiochem®

Synonym(s):

Anti-p150, Anti-Abl

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About This Item

UNSPSC Code:
12352203

biological source

mouse

Quality Level

100

antibody product type

primary antibodies

clone

19-110, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

mouse, human

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

isotype

IgG1

shipped in

wet ice

storage temp.

2-8°C

General description

Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specifed immunogen and fusing splenocytes with P.3U1 mouse myeloma cells (see application references). Recognizes the v-abl, CML c-brc/abl p210, human ALL c-brc/abl p190, human c-abl p145, and mouse c-abl p150 proteins.
Recognizes the ~145 kDa human c-Abl, the ~150 kDa mouse c-Abl, v-Abl proteins, and the Bcr/Abl translocation products in ALL (~190 kDa) and CML (~210 kDa).
  • Antibody Target Gene Symbol: ABL1
  • Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl
  • Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
  • Hu Entrez ID: 25 (Related Antibodies: OP20PK1006PK1013)
  • Mu Entrez ID: 11350
  • Rat Entrez ID: 311860

    • Immunogen

    a TrpE-v-Abl fusion protein

    Application

    Immunoblotting (1-5 µg/ml)

    Immunoprecipitation (1-2 µg/sample)

    Neutralization Studies (see application references)

    Packaging

    Please refer to vial label for lot-specific concentration.

    Physical form

    In 50 mM sodium phosphate buffer, 0.2% gelatin.

    Analysis Note

    Positive Control
    K562 (human bcr/abl protein), ANN-1 (mouse abl protein), HL-60 (human normal abl protein), or NIH 3T3 (mouse normal abl protein) cells

    Other Notes

    Inhibits tyrosine kinase activity (see application references). Antibody should be titrated for optimal use in individual systems.
    Wiedemann, L.M., et al. 1988. Blood71, 349.
    Schiff-Maker, L., Buet al. 1986. J. Virol.57, 1182.
    Stam, K., et al. 1985. N. Engl. J. Med.313, 1429.
    Konopka, J.B., et al. 1984. Cell37, 1035.
    Prywes, R., et al. 1983. Cell34, 569.
    de Klein, et al. 1982. Nature300, 765. 1982.
    Reynolds, F.H., et al. 1980. J. Virol.36, 374.
    Reynolds, F.H., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 3974.
    Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA75, 2488. 1978.
    Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res.30, 2213.

    Legal Information

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

    Disclaimer

    Toxicity: Standard Handling (A)

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    Jianling Yang et al.
    Cancer research, 73(15), 4898-4908 (2013-06-12)
    Alterations in translation occur in cancer cells, but the precise pathogenic processes and mechanistic underpinnings are not well understood. In this study, we report that interactions between Pim family kinases and the translation initiation factor eIF4B are critical for Abl

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