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Merck

RSHMAG-69K

MILLIPLEX® Rat Stress Hormone Panel

Configurable Rat Stress Hormone 3-Plex Panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Product Name

MILLIPLEX® Rat Stress Hormone Panel, Configurable Rat Stress Hormone 3-Plex Panel

species reactivity

rat

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 61%
(Corticosterone)
accuracy: 83%
(ACTH)
sensitivity: 0.9 pg/mL
(ACTH)
sensitivity: 1.52 pg/mL
(Melatonin)
sensitivity: 2914 pg/mL
(Corticosterone)
standard curve range: 0.55-400 pg/mL
(Melatonin)
standard curve range: 1.4-1,000 pg/mL
(ACTH)
standard curve range: 686-500,000 pg/mL
(Corticosterone)
inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)
tissue/cellular extract(s)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 3 analytes in rat serum, plasma, tissue lysate, or cell culture supernatants.

Analytes Included: ACTH, Corticosterone, Melatonin Note: For optimal performance of turbid serum and plasma samples, an extraction protocol is provided.

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Features:

  • Measures ACTH, Corticosterone, and Melatonin in a single assay
  • Suitable for rat serum, plasma, and tissue lysates
  • High sensitivity and specificity for low-abundance stress biomarkers
  • Multiplex format reduces sample volume and assay time
  • Verified under stringent Quality Control standards
Benefits:

  • Enables comprehensive profiling of stress and circadian-related hormones
  • Supports research into HPA axis function and neuroendocrine regulation
  • Improves efficiency by consolidating multiple assays into one
  • Delivers reliable and reproducible data for behavioral and toxicological studies
  • Facilitates longitudinal and comparative studies in rodent stress models

General description

ACTH (Adrenocorticotropic Hormone), Corticosterone, and Melatonin are key indicators of physiological stress and circadian rhythm regulation. ACTH stimulates the adrenal cortex to release corticosterone, a primary stress hormone in rodents, while melatonin modulates sleep-wake cycles and is influenced by light exposure and stress. Measuring these analytes provides valuable insights into neuroendocrine function, HPA axis activity, and behavioral stress responses in rodent models, supporting research in neuroscience, endocrinology, and toxicology.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brooks A Gross et al.
Journal of neuroscience methods, 251, 83-91 (2015-05-28)
Sleep deprivation via gentle handling is time-consuming and personnel-intensive. We present here an automated sleep deprivation system via air puffs. Implanted EMG and EEG electrodes were used to assess sleep/waking states in six male Sprague-Dawley rats. Blood samples were collected
Viviane S Hambrecht-Wiedbusch et al.
Sleep, 40(9) (2017-09-22)
Sleep and pain are reciprocally related, but the precise mechanisms underlying this relationship are poorly understood. This study used a rat model of surgical pain to examine the effect of previous sleep loss on postoperative pain and tested the hypothesis
Vitor Silva Pereira et al.
Acta neuropsychiatrica, 31(5), 258-265 (2019-06-25)
Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant depression, among them repeated treatment with Adrenocorticotropic hormone (ACTH) appears to be useful to
Chris P Jew et al.
PloS one, 8(8), e70415-e70415 (2013-08-14)
The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism. mGluR5-dependent synaptic plasticity has been described at a variety of neural connections and its signaling has been
Tala Khazen et al.
Scientific reports, 9(1), 12270-12270 (2019-08-24)
The limbic circuit is still undergoing maturation during juvenility and adolescence, explaining why environmental and metabolic challenges during these developmental periods can have specific adverse effects on cognitive functions. We have previously shown that long-term exposure (8-12 weeks) to high-fat
View All Related Papers

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Global Trade Item Number

SKUGTIN
RSHMAG-69K-0104053252931499
RSHMAG-69K-0204053252931505
RSHMAG-69K-0304053252931512

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