C3805

Cyclophilin A human

Name: Cyclophilin A human
Brand: SIGMA

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution

Synonym(s):

CyP

Select a Size

All Photos(1)

About This Item

CAS Number:

95076-93-0

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

5.2.1.8 (BRENDA, IUBMB)

MDL number:

MFCD00130885

Product Name

Cyclophilin A human, ≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

mol wt

20 kDa

concentration

≥0.3 mg/mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P62937

storage temp.

−20°C

Quality Level

200

Gene Information

human ... PPIA(5478)

Application

Cyclophilin A human has been used in the study to interpret the mechanisms by which extracellular CyPA initiates endothelial activation.

Biochem/physiol Actions

Cyclophilin A (CyPA) participates in intracellular signalling and protein trafficking. It helps to control other proteins activity. CyPA plays a physiological and pathological role in cardiovascular diseases. Hence it acts as an important biomarker and mediator in several cardiovascular diseases, like vascular stenosis, atherosclerosis and abdominal aortic aneurysms. CyPA can induce the proliferation and inflammatory cell migration of vascular smooth muscle cells (VSMC) in vitro and in vivo.

Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al.

General description

Cyclophilins are a family of extremely conserved proteins, known as immunophilins. Cyclophilin A (CyPA) is present in all tissues in prokaryotes and eukaryotes. It is present in all organs of human. Cyclophilin A (CyPA), a 20 kDa chaperone protein, that is liberated from vascular smooth muscle cells (VSMCs).

Physical form

Composed of amino acids 1-165 plus an N-terminal 20 amino acid His-tag

Solution in 20mM Tris, pH 8.0, containing 20 mM NaCl, 0.5 mM DTT and 10% glycerol

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cyclosporine A normalizes mitochondrial coupling, reactive oxygen species production, and inflammation and partially restores skeletal muscle maximal oxidative capacity in experimental aortic cross-clamping.

Julien Pottecher et al.

Journal of vascular surgery, 57(4), 1100-1108 (2013-01-22)

By binding to cyclophilin D, cyclosporine A (CsA) inhibits mitochondrial permeability transition pore (mPTP) opening and prevents mitochondrial dysfunction and ultimately cell death after ischemia-reperfusion (IR) injury in cardiac muscle. This study tested whether CsA would decrease skeletal muscle oxidative

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation.

Roger van Kruchten et al.

Blood, 121(10), 1850-1857 (2013-01-11)

Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and

Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs.

Päivi Pihlajamaa et al.

The EMBO journal, 33(4), 312-326 (2014-01-24)

Androgen receptor (AR) binds male sex steroids and mediates physiological androgen actions in target tissues. ChIP-seq analyses of AR-binding events in murine prostate, kidney and epididymis show that in vivo AR cistromes and their respective androgen-dependent transcription programs are highly

Cyclophilin A

Satoh K, et al.

Circulation Journal, 74(11), 2249-2256 (2010)

Immunological functions of the neuropilins and plexins as receptors for semaphorins.

Atsushi Kumanogoh et al.

Nature reviews. Immunology, 13(11), 802-814 (2013-12-10)

Semaphorins were originally identified as axon-guidance molecules that function during neuronal development. However, cumulative evidence indicates that semaphorins also participate in immune responses, both physiological and pathological, and they are now considered to be potential diagnostic and/or therapeutic targets for

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service