G8294
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
MDL number:
Product Name
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse
technique(s)
immunohistochemistry: 1 μg/mL using mouse embryo brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GNRH1(2796)
mouse ... Gnrh1(14714)
rat ... Gnrh1(25194)
Application
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit is suitable for immunoprecipitation of GnRH purified from adult amphioxus tissues. It is suitable for immunohistochemistry at a working concentration of 1μg/mL using mouse embryo brain.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Gonadotropin releasing hormone (GnRH) is crucial for the regulation of reproduction in vertebrates. It is a decapeptide and is expressed by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. Neural, hormonal and environmental stimuli affect the generation of GnRH pulses, which in turn affect the secretion of follicle stimulating hormone(FSH) and luteinizing hormone (LH) from the pituitary. It may be involved in mediating cancers of the reproductive system.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
synthetic peptide pyroEHWSYGLRP(G-NH2) corresponding to human GnRH. The sequence is completely conserved in rat and tree shrew and 78% conserved in zebrafish.
Physical form
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Erica E Davis et al.
Human molecular genetics, 29(14), 2435-2450 (2020-07-06)
Dysfunction of the gonadotropin-releasing hormone (GnRH) axis causes a range of reproductive phenotypes resulting from defects in the specification, migration and/or function of GnRH neurons. To identify additional molecular components of this system, we initiated a systematic genetic interrogation of
Jiao Zhu et al.
Journal of neuroscience research, 93(10), 1611-1621 (2015-06-19)
Gonadotropin-releasing hormone (GnRH) neurons play a pivotal role in reproductive function. GnRH is released in distinct pulses that are regulated by neurotransmitters or neuromodulators. With immunohistochemistry and GAD67-GFP knockin mice, this study shows for the first time that a subset
Green light inhibits GnRH-I expression by stimulating the melatonin-GnIH pathway in the chick brain.
L Zhang et al.
Journal of neuroendocrinology, 29(5) (2017-03-16)
To study the mechanism by which monochromatic light affects gonadotrophin-releasing hormone (GnRH) expression in chicken hypothalamus, a total of 192 newly-hatched chicks were divided into intact, sham-operated and pinealectomy groups and exposed to white (WL), red (RL), green (GL) and
J E Hall et al.
The Journal of clinical endocrinology and metabolism, 67(3), 524-531 (1988-09-01)
The differential regulation of immunoactive FSH and LH secretion by endogenous GnRH was studied using a GnRH antagonist, [Ac-D2Nal1,D4FPhe2,DTrp3,DArg6]GnRH (the NAL-ARG antagonist), in normal women in the early follicular phase of the menstrual cycle, and their responses were compared to
R M Moretti et al.
Endocrine-related cancer, 10(2), 161-167 (2003-06-07)
Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions. In recent years, it has become evident that LHRH might act as a growth modulatory factor in tumors of the reproductive system. We have shown that
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