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  • Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery.

Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery.

Clinical epigenetics (2017-09-09)
Samantha E Day, Luis A Garcia, Richard L Coletta, Latoya E Campbell, Tonya R Benjamin, Elena A De Filippis, James A Madura, Lawrence J Mandarino, Lori R Roust, Dawn K Coletta
PMID28883895
ABSTRACT

Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can influence gene transcription. The aim of our study was to investigate skeletal muscle DNA methylation of sorbin and SH3 domain containing 3 ( Previously, we had shown increased methylation (5.0 to 24.4%) and decreased gene expression (fold change - 1.9) of These results demonstrate that