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  • Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin.

Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin.

FEBS letters (1993-10-11)
E Balza, A Siri, M Ponassi, F Caocci, A Linnala, I Virtanen, L Zardi
PMID7691659
ABSTRACT

We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.