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171259 AMPK Activator III, DHPO - Calbiochem

The AMPK Activator III, DHPO modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

AMPK Activator III, DHPO - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₃H₉NO₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr172) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.
      Catalogue Number171259
      Brand Family Calbiochem®
      Synonyms1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
      References
      ReferencesKandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.
      Product Information
      FormOrange solid
      Hill FormulaC₁₃H₉NO₂
      Chemical formulaC₁₃H₉NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      171259 0

      Documentation

      AMPK Activator III, DHPO - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AMPK Activator III, DHPO - Calbiochem Certificates of Analysis

      TitleLot Number
      171259

      References

      Reference overview
      Kandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2010 RFH
      Synonyms1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
      DescriptionA cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr172) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.
      FormOrange solid
      Chemical formulaC₁₃H₉NO₂
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesKandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.