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Description
Overview
An antiviral nucleoside analog. Inhibits the proliferation of NIH 3T3 fibroblastic cells transformed by either v-abl or bcr-abl. Synchronizes OM9:22 leukemia cells at the G0/G1 phase of the cell cycle.
Nishimaki, J., et al. 1996. Leuk. Res. 20, 415. Cioé, L., et al. 1992. J. Biol. Chem. 267, 22178. Whitley, R.J., and Gnann, J.W., Jr. 1992. N. Engl. J. Med. 327, 782.
Acyclovir - CAS 59277-89-3 - Calbiochem Certificates of Analysis
Title
Lot Number
114798
References
Reference overview
Nishimaki, J., et al. 1996. Leuk. Res. 20, 415. Cioé, L., et al. 1992. J. Biol. Chem. 267, 22178. Whitley, R.J., and Gnann, J.W., Jr. 1992. N. Engl. J. Med. 327, 782.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An antiviral agent. Inhibits the proliferation of NIH 3T3 fibroblastic cells transformed by either v-abl or brc-abl. Synchronizes OM9; 22 leukemia cells at the Go/G1 phase of the cell cycle.
Form
White solid
CAS number
59277-89-3
RTECS
UP0791400
Chemical formula
C₈H₁₁N₅O₃
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (5 mg/ml) or 1M HCl (50 mg/ml) (solutions may be hazy)
Storage
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity
Standard Handling
Merck USA index
14, 146
References
Nishimaki, J., et al. 1996. Leuk. Res. 20, 415. Cioé, L., et al. 1992. J. Biol. Chem. 267, 22178. Whitley, R.J., and Gnann, J.W., Jr. 1992. N. Engl. J. Med. 327, 782.
