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119148 Adenosine A1 Receptor Antagonist II, PSB-36 - CAS 524944-72-7 - Calbiochem

A highly potent and selective antagonist of adenosine A1 receptor (Ki = 124 and 700 pM for rat and human A1R, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36

119148
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      524944-72-7C₂₁H₃₀N₄O₃
      Description
      OverviewA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
      Catalogue Number119148
      Brand Family Calbiochem®
      Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
      References
      ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
      Weyler, S., et al. 2006. ChemMedChem. 1, 891.
      Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
      Product Information
      CAS number524944-72-7
      FormTan powder
      Hill FormulaC₂₁H₃₀N₄O₃
      Chemical formulaC₂₁H₃₀N₄O₃
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      119148 0

      Documentation

      Adenosine A1 Receptor Antagonist II, PSB-36 - CAS 524944-72-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      119148

      References

      Reference overview
      Bilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
      Weyler, S., et al. 2006. ChemMedChem. 1, 891.
      Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
      DescriptionA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
      FormTan powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number524944-72-7
      Chemical formulaC₂₁H₃₀N₄O₃
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
      Weyler, S., et al. 2006. ChemMedChem. 1, 891.
      Tupfer, M., et al. 2008. Cell Biochem. 25, 833.