116850 Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

116850
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₂H₁₁N₃O₂299442-43-6

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
116850-25MG
Retrieving availability...
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 25 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      116850-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
          Catalogue Number116850
          Brand Family Calbiochem®
          Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
          References
          ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.
          Product Information
          CAS number299442-43-6
          ATP CompetitiveN
          FormPale orange solid
          Hill FormulaC₁₂H₁₁N₃O₂
          Chemical formulaC₁₂H₁₁N₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAdenylate cyclase (AC) type V isoform
          Primary Target IC<sub>50</sub>8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          116850

          References

          Reference overview
          Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
          DescriptionA cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G5α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.
          FormPale orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number299442-43-6
          Chemical formulaC₁₂H₁₁N₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.