116850 Sigma-AldrichAdenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

The Adenylyl Cyclase Type V Inhibitor, NKY80, also referenced under CAS 299442-43-6, controls the biological activity of Adenylyl Cyclase Type V. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: 2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone

Primary Target: Adenylate cyclase (AC) type V isoform

Recommended Products

Overview

Replacement Information

Key Spec Table

CAS #	Empirical Formula
299442-43-6	C₁₂H₁₁N₃O₂

Pricing & Availability

Catalogue Number	Availability	Packaging	Qty/Pack	Price	Quantity
116850-25MG	Retrieving availability... — Fulfilment and delivery delayed In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Fulfilment and delivery delayed In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	25 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites
116850-5MG	Retrieving availability... — Fulfilment and delivery delayed In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Fulfilment and delivery delayed In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	5 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Catalogue Number	116850
Brand Family	Calbiochem®
Synonyms	2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone

References
References	Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.

Product Information
CAS number	299442-43-6
ATP Competitive	N
Form	Pale orange solid
Hill Formula	C₁₂H₁₁N₃O₂
Chemical formula	C₁₂H₁₁N₃O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Adenylate cyclase (AC) type V isoform
Primary Target IC<sub>50</sub>	8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem Certificates of Analysis

Title	Lot Number
116850	Enter Lot Number

References

Reference overview
Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
Description	A cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G₅α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.
Form	Pale orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	299442-43-6
Chemical formula	C₁₂H₁₁N₃O₂
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (200 mg/ml) or Methanol (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.