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MABC44 Anti-LAMP-3 Antibody, clone 16H11.2

Detect LAMP-3 using this Anti-LAMP-3 Antibody, clone 16H11.2 validated for use in WB, IH.

Anti-LAMP-3 Antibody, clone 16H11.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Apoptosis - Additional, Organelle & Cell Markers Gene Symbol: LAMP3, DCLAMP, TSC403 UniProt Number: Q9UQV4
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MABC44
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC44
      DescriptionAnti-LAMP-3 Antibody, clone 16H11.2
      Alternate Names
      • LAMP
      • CD208
      • LAMP-3
      • DC-loysosome-associated membrane glycoprotein
      • DC LAMP
      • DC-LAMP
      • Protein TSC403
      Background InformationLysosyme-associated membrane proteins (LAMP) are transmembrane lysosomal glycoproteins, which share a common Gly-Tyr motif as a lysosomal targeting signal. While LAMP-1 and LAMP-2 contain type 1 transmembrane domains, LAMP-3 contains a transmembrane 4 superfamily domain, tetraspanin. FceRI-mediated stimulation of basophils causes LAMP-3 to be translocated from its intracellular localization to the plasma membrane. LAMP-3 thereby serves as a reliable marker for basophil activation. LAMP-3 expression is known to be reported in human bone marrow mast cells and in leukemic human mast cell line (HMC-1), among other cell lines. LAMP3 is shown to be regulated by hypoxia in a panel of tumor cells, via the unfolded protein response (UPR). UPR is a mechanism of adaptation to endoplasmic reticulum stress and is demonstrated to contribute to hypoxic adaptation in tumors through multiple mechanisms.
      References
      Product Information
      FormatPurified
      Control
      • MCF-7 cell lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect LAMP-3 using this Anti-LAMP-3 Antibody, clone 16H11.2 validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200 dilution from a representative lot detected LAMP-3 in colorectal adenocarcinoma tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to human LAMP-3.
      Clone16H11.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryDendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998).
      Gene Symbol
      • LAMP3
      • DCLAMP
      • TSC403
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells.

      SUBCELLULAR LOCALIZATION: Lysosome membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
      Molecular Weight ~65 kDa observed.
      The calculated molecular weight of this protein is 41 kDa, but has been observed at ~65-90 kDa due to glycosolation (de Saint-Vis, B., et al. (1998). Immunity. 9(3):325-336).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-3 in MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC44 04053252521423

      Documentation

      Anti-LAMP-3 Antibody, clone 16H11.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LAMP-3 Antibody, clone 16H11.2 Certificates of Analysis

      TitleLot Number
      Anti-LAMP-3, clone 16H11.2 - 2201475 2201475
      Anti-LAMP-3, clone 16H11.2 - 2273849 2273849
      Anti-LAMP-3, clone 16H11.2 - 2309322 2309322
      Anti-LAMP-3, clone 16H11.2 - 3179194 3179194
      Anti-LAMP-3, clone 16H11.2 - 3352421 3352421
      Anti-LAMP-3, clone 16H11.2 - 3503452 3503452
      Anti-LAMP-3, clone 16H11.2 - 3842850 3842850
      Anti-LAMP-3, clone 16H11.2 - NRG1897821 NRG1897821
      Anti-LAMP-3, clone 16H11.2 -2527582 2527582
      Anti-LAMP-3, clone 16H11.2 -2724175 2724175
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