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MABS186 Anti-LOX-1, clone 9E12.1

Anti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

Anti-LOX-1, clone 9E12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: OLR1, CLEC8A, LOX1 UniProt Number: P78380
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MABS186
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS186
      DescriptionAnti-LOX-1, clone 9E12.1
      Alternate Names
      • LOX-1
      • Oxidized low-density lipoprotein receptor 1
      • Ox-LDL receptor 1
      • C-type lectin domain family 8 member A
      • Lectin-like oxidized LDL receptor 1
      • Lectin-like oxLDL receptor 1
      • hLOX-1
      • Lectin-type oxidized LDL receptor 1
      • Oxidized low-density lipoprotein receptor 1, soluble form
      Background InformationLOX1 is a plasma membrane receptor, that also has a free soluble receptor form, that is the receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. LOX1 is also the receptor for HSP70, and LOX1 acts as a leukocyte adhesion molecule on glycosylated proteins present on platelets, monocytes, bacteria, apoptotic cells in inflammatory responses.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LOX-1 in human placenta tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human LOX-1.
      Clone9E12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OLR1
      • CLEC8A
      • LOX1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~35 kDa observed. The calculated molecular weight of this protein is 31 kDa, but can be observed at ~33-37 kDa due to high glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in KG-1 cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected LOX-1 in 200 µg of KG-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS186 04055977135367

      Documentation

      Anti-LOX-1, clone 9E12.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LOX-1, clone 9E12.1 Certificates of Analysis

      TitleLot Number
      Anti-LOX-1, clone 9E12.1 - 3191404 3191404
      Anti-LOX-1, clone 9E12.1 - 3532303 3532303
      Anti-LOX-1, clone 9E12.1 - 3670610 3670610
      Anti-LOX-1, clone 9E12.1 - 3923043 3923043
      Anti-LOX-1, clone 9E12.1 - 4070063 4070063
      Anti-LOX-1, clone 9E12.1 - 4252113 4252113
      Anti-LOX-1, clone 9E12.1 - 4315664 4315664
      Anti-LOX-1, clone 9E12.1 -2892459 2892459
      Anti-LOX-1, clone 9E12.1 -Q2550834 Q2550834
      Anti-LOX-1, clone 9E12.1 Monoclonal Antibody 2872172
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      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.