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MABF96 Anti-TRAcP Antibody, clone 9C5

Anti-TRAcP Antibody, clone 9C5 detects level of TRAcP & has been published & validated for use in IH, IP, DB, ELISA, IC & WB.

Anti-TRAcP Antibody, clone 9C5 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: ACP5 UniProt Number: P13686
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MABF96
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, IP, DB, ELISA, ICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF96
      DescriptionAnti-TRAcP Antibody, clone 9C5
      Alternate Names
      • Tartrate-resistant acid phosphatase type 5
      • TR-AP
      • Tartrate-resistant acid ATPase
      • TrATPase
      • Type 5 acid phosphatase
      Background InformationTartrate-resistant acid phosphatase type 5 (TRAcP), also referred to as Acp5, is secreted by osteoclasts during bone resorption. Release of TRAcP was stimulated by resorbogenic cytokines and repressed by calcitonin (a resorption inhibitor). TRAcP is also known to be expressed in high quantities in active macrophages and dendritic cells and play an essential part in presenting antigens to T cells. Inactive TRAcP released from adipose tissue macrophages has been shown to bring on hyperplastic obesity, keeping lipid metabolism and insulin sensitivity normal.
      References
      Product Information
      FormatPurified
      Control
      • Large malignant B-cells in hairy cell leukemia tissue
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TRAcP Antibody, clone 9C5 detects level of TRAcP & has been published & validated for use in IH, IP, DB, ELISA, IC & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Dot Blot
      • ELISA
      • Immunocytochemistry
      • Western Blotting
      Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in WB. (Janckila, A.J., et al. (1995). Blood. 85:2839-2844.)

      Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Janckila, A.J., et al. (1995). Blood. 85:2839-2844.)

      Dot Blot Analysis: A representative lot was used by an independent laboratory in DB. (Janckila, A.J., et al. (1995). Blood. 85:2839-2844.)

      ELISA Analysis: A representative lot was used by an independent laboratory in ELISA. (Janckila, A.J., et al. (1995). Blood. 85:2839-2844.)

      Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Janckila, A.J., et al. (1996). The Journal of Histochemistry and Cytochemistry. 44(3):233-244.)
      Biological Information
      ImmunogenFull length purified protein corresponding to human TRAcP.
      Clone9C5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq].
      Gene Symbol
      • ACP5
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

      CATALYTIC ACTIVITY: A phosphate monoester + H2O = an alcohol + phosphate.

      COFACTOR: Binds 2 iron ions per subunit.

      SUBUNIT STRUCTURE: Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

      SUBCELLULAR LOCATION: Lysosome.

      SEQUENCE SIMILARITIES: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
      Molecular Weight36 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in large malignant B-cells in hairy cell leukemia tissue.

      Immunohistochemistry Analysis: 1:500 dilution of this antibody detected TRAcP in large malignant B-cells in hairy cell leukemia tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF96 04053252750748

      Documentation

      Anti-TRAcP Antibody, clone 9C5 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TRAcP Antibody, clone 9C5 Certificates of Analysis

      TitleLot Number
      Anti-TRAcP, clone 9C5 3068473
      Anti-TRAcP, clone 9C5 - 2388986 2388986
      Anti-TRAcP, clone 9C5 - 2464632 2464632
      Anti-TRAcP, clone 9C5 - 2465454 2465454
      Anti-TRAcP, clone 9C5 - 2055301 2055301
      Anti-TRAcP, clone 9C5 - 2179372 2179372
      Anti-TRAcP, clone 9C5 - 2283572 2283572
      Anti-TRAcP, clone 9C5 - 2328390 2328390
      Anti-TRAcP, clone 9C5 - 2367818 2367818
      Anti-TRAcP, clone 9C5 - 3675947 3675947
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