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ABC114 Anti-Thrombospondin-2 Antibody

Anti-Thrombospondin-2 Antibody is an antibody against Thrombospondin-2 for use in Western Blotting.

Anti-Thrombospondin-2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: THBS2, TSP2 UniProt Number: P35442
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ABC114
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC114
      DescriptionAnti-Thrombospondin-2 Antibody
      Alternate Names
      • Thrombospondin-2
      Background InformationThrombospondins (TSPs) are a family of homotrimeric multi-domain glycoproteins involved in modulation of cell adhesion, proliferation, and migration and have been implicated clinically in the development of atherosclerosis, angiogenesis, and oncogenesis. TSP2, a member of the thrombospondin family is a secreted protein, but is present only transiently in extracellular matrix and is rapidly internalized for degradation by fibroblasts after binding to the cell surface. It also interacts with matrix metalloproteinases (MMPs) and matrix serine proteases, such as plasminogen activator. TSP2 is reportedly controls the apoptosis-proliferation balance in endothelial cells. Although TSP2 is a potent inhibitor of angiogenesis, its N-terminal region exhibits pro-angiogenic activities mediated by beta 1 integrins. Loss of TSP2 expression is associated with local invasive behavior, tumor neovascularization, and metastasis. Decreased TSP2 expression has been correlated with malignant progression and angiogenesis in some cancers. TSP2 levels are also highly expressed in developing and healing tissues.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Concentrated conditioned media from MG-63 cells
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Thrombospondin-2 Antibody is an antibody against Thrombospondin-2 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the Laminin G-like region of human Thrombospondin-2.
      EpitopeLaminin G-like region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the Laminin G-like region of Thrombospondin-2.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. Other homologies: Mouse, Rat, and Bovine (93% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • THBS2
      • TSP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~180 kDa observed. The calculated molecular weight is 130 kDa, however Thrombospondin-2 has been shown to have bands at ~135 kDa and ~180 kDa in western blots (Streit, M., et al. (1999). PNAS. 96(26):14888-14893).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in concentrated conditioned media from MG-63 cells.

      Western Blot Analysis: 0.25 µg/mL of this antibody detected Thrombospondin-2 in 10 µg of concentrated conditioned media from MG-63 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC114 04053252819261

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies