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MABC572 Anti-c-Ret Antibody, clone 6F3.1

This Anti-c-Ret Antibody, clone 6F3.1 is validated for use in Western Blotting for the detection of c-Ret.

Anti-c-Ret Antibody, clone 6F3.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: RET, CDHF12, CDHR16, PTC, RET51 UniProt Number: P07949
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MABC572
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC572
      DescriptionAnti-c-Ret Antibody, clone 6F3.1
      Alternate Names
      • Proto-oncogene tyrosine-protein kinase receptor Ret
      • Cadherin family member 12
      • Proto-oncogene c-Ret
      Background InformationProto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1; UniProt P07949; also known as Cadherin family member 12, Cadherin-related family member 16, Hydroxyaryl-protein kinase, Proto-oncogene c-Ret, Rearranged during transfection, Receptor tyrosine kinase, Ret proto-oncogene, RET receptor tyrosine kinase, RET transforming sequence) is encoded by the RET (also known as CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51) gene (Gene ID 5979) in human. Ret is a receptor tyrosine kinase that mediates the activation of several signaling pathways including the PLC gamma, Ras, JNK and inositol phosphate pathways. Ret mutations have been shown to be causative in several diseases, including Hirschsprung's disease (HD), papillary thyroid carcinoma, multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma. Ret is initially produced with a signal peptide sequence (a.a. 1-28), the removal of which yields the mature Ret (a.a. 20-1114). Ret can be posttranslationally cleaved into the extracellular cell-membrane-anchored RET cadherin 120 kDa fragment (a.a. 29-707) and the soluble RET kinase fragment (a.a. 708-1017).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-c-Ret Antibody, clone 6F3.1 is validated for use in Western Blotting for the detection of c-Ret.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the extracellular domain of human c-Ret.
      EpitopeExtracellular domain
      Clone6F3.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both the RET51 and the RET9 isoforms, as well as the extracellular cell-membrane anchored RET cadherin 120 kDa fragment (a.a. 29-707).
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RET
      • CDHF12
      • CDHR16
      • PTC
      • RET51
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~150 kDa observed. 124.3 kDa (RET51) and 119.8 kDa (RET9) calculated. Target band(s) may appear larger than the calculated molecular size(s) due to posttranslational glycosylation and/or phosphorylation. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC12 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected c-Ret in 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC572 04055977288322