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260961 DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem

DNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646

Primary Target: DNA-PK
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      154447-35-5C₁₇H₁₅NO₃
      Description
      OverviewA cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC50 of 0.23 µM. It is highly selective towards DNA-PK over PI3K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR.
      Catalogue Number260961
      Brand Family Calbiochem®
      SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
      References
      ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
      Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
      Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
      Product Information
      CAS number154447-35-5
      ATP CompetitiveY
      FormCrystalline solid
      Hill FormulaC₁₇H₁₅NO₃
      Chemical formulaC₁₇H₁₅NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).
      Biological Information
      Primary TargetDNA-PK
      Primary Target IC<sub>50</sub>0.23 µM against DNA-PK
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      260961 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      260961

      References

      Reference overview
      Willmore, E., et al. 2004. Blood,103, 4659.
      Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
      Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-January-2010 RFH
      SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
      DescriptionA cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM). Reported to be highly selective for DNA-PK compared to PI3 K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR). Exhibits no inhibitory effect on PARP-1. Shown to inhibit DNA-PK-mediated, but not PARP-1-mediated, cellular DNA double strand break (DSB) repair and potentially lethal damage recovery (PLDR) following ionizing radiation (IR). Also shown to sensitize both proliferating and quiescent cells to IR.
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number154447-35-5
      Chemical formulaC₁₇H₁₅NO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (2 mg/ml) or Methanol (700 µg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
      Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
      Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.