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SCC186 DOV13 Human Ovarian Carcinoma Cell Line

The DOV13 human ovarian carcinoma cell line is a highly characterized model for metastatic ovarian cancer studies.

SCC186
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC186
      DescriptionDOV13 Human Ovarian Carcinoma Cell Line
      OverviewThe DOV13 human ovarian carcinoma cell line is one of the most studied and characterized cellular models for metastatic ovarian cancers, having been utilized in many cellular studies focusing on cellular migration and invasion. DOV13 cells are responsive to vascular endothelial growth factor (VEGF) (2), express estrogen receptor (3) and matrilysin (MMP-7), a marker of metastatic and invasive epithelial carcinomas (4), and secrete the proteolytic factor matrix metalloproteinase-2 (MMP-2) (5). DOV13 cells are genetically well-characterized and harbor deletion of the tumor suppressor CDKN2A (6). The characteristics of the DOV13 cell line make it a pertinent model for the most malignant ovarian cancer.

      Source:
      The DOV13 human ovarian carcinoma cell line was isolated from ovarian adenocarcinoma tissue (2).
      Alternate Names
      • DOV-13
      • DOV 13
      Background InformationEpithelial carcinomas are the most common ovarian cancer, accounting for 90 percent of cases. Ovarian carcinoma is typically diagnosed at late stage after cancer has metastasized beyond the ovaries, greatly reducing treatment options and contributing to the poor survival rate of this cancer type (1). Robust cellular models have been essential to understanding the mechanisms of ovarian cancer metastasis and development of potential therapeutic strategies.

      References:
      1. Nat Rev Dis Primers. 2016; 2:16061.
      2. Am J Obstet Gynecol. 1992; 166(2): 676-684.
      3. Proc Natl Acad Sci USA..1999; 96(10): 5722-5727.
      4. Int J Cancer. 2005; 114(1): 19-31.
      5. J Biol Chem. 1995; 270(3): 999-1002.
      6. Nucleic Acid Res. 2019; 47(D1): D941-D947.
      References
      Product Information
      Applications
      ApplicationThe DOV13 human ovarian carcinoma cell line is a highly characterized model for metastatic ovarian cancer studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC186 04061841074984

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