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05-23-3801 Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem

Attenuates thrombin-evoked aggregation of human platelets.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ET-3, CTCFTYKDKECVYYCHLDIIW

Primary Target: Stimulator of interleukin-6 production by endothelial cell lines
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05-23-3801
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117399-93-6C₁₂₁H₁₆₈N₂₆O₃₃S₄

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      Description
      OverviewAttenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      Catalogue Number05-23-3801
      Brand Family Calbiochem®
      SynonymsET-3, CTCFTYKDKECVYYCHLDIIW
      References
      ReferencesGresser, O., et al. 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
      Xin, X., et al. 1995. Endocrinology 136, 132.
      Brunner, F., et al. 1992. J. Mol. Cell. Cardiol. 24, 1291.
      Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
      Product Information
      CAS number117399-93-6
      ATP CompetitiveN
      FormSolid
      FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
      Hill FormulaC₁₂₁H₁₆₈N₂₆O₃₃S₄
      Chemical formulaC₁₂₁H₁₆₈N₂₆O₃₃S₄
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetStimulator of interleukin-6 production by endothelial cell lines
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      05-23-3801-0.5MG 04055977226805

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      05-23-3801

      References

      Reference overview
      Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
      Xin, X., et al. 1995. Endocrinology 136, 132.
      Brunner, F., et al. 1992. J. Mol. Cell. Cardiol. 24, 1291.
      Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-September-2008 RFH
      SynonymsET-3, CTCFTYKDKECVYYCHLDIIW
      DescriptionAttenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ETA receptors.
      FormSolid
      FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
      CAS number117399-93-6
      Chemical formulaC₁₂₁H₁₆₈N₂₆O₃₃S₄
      Peptide SequenceH-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Purity≥97% by HPLC
      Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      ReferencesGresser, O., et al. 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
      Xin, X., et al. 1995. Endocrinology 136, 132.
      Brunner, F., et al. 1992. J. Mol. Cell. Cardiol. 24, 1291.
      Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.