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361554 GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Neurogenesis Inducer, TWS119

Primary Target: GSK-3β
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361554
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
601514-19-6C₁₈H₁₄N₄O₂

Pricing & Availability

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      361554-5MG
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          Description
          OverviewA cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
          Catalogue Number361554
          Brand Family Calbiochem®
          SynonymsNeurogenesis Inducer, TWS119
          References
          ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
          Product Information
          CAS number601514-19-6
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₁₈H₁₄N₄O₂
          Chemical formulaC₁₈H₁₄N₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetGSK-3β
          Primary Target IC<sub>50</sub>30 nM; Kd = 126 nM against GSK-3β
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          361554-1MG 04055977214123
          361554-5MG 04055977214130

          Documentation

          Required Licenses

          Title
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          361554

          References

          Reference overview
          Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.

          Brochure

          Title
          Stem Cell Resource Brochure GBP
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsNeurogenesis Inducer, TWS119
          DescriptionA cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number601514-19-6
          Chemical formulaC₁₈H₁₄N₄O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol (2 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.