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374085 HELSS

A potent, cell-permeable, and irreversible inhibitor of calcium-independent phospholipase A₂ (PLA₂; IC₅₀ = 60 nM).

HELSS MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BEL, E-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one, Haloenol lactone suicide substrate

Primary Target: Calcium-independent phospholipase A2 (PLA2)
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      88070-98-8C₁₆H₁₃BrO₂
      Description
      Overview

      This product has been discontinued.





      A potent, cell-permeable, and irreversible inhibitor of calcium-independent phospholipase A2 (PLA2; IC50 = 60 nM). Exhibits 1000-fold higher selectivity for calcium-independent PLA2 versus calcium-dependent PLA2. Inhibits the release of prostaglandin E2 and suppresses glucose-stimulated release of insulin from pancreatic β cells.
      Catalogue Number374085
      Brand Family Calbiochem®
      SynonymsBEL, E-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one, Haloenol lactone suicide substrate
      References
      ReferencesAckermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
      Lehman, J.J., et al. 1993. J. Biol. Chem. 268, 20713.
      Ramanadham, S., et al. 1993. Biochemistry 32, 337.
      Hazen, S.L., et al. 1991. J. Biol. Chem. 266, 7227.
      Product Information
      CAS number88070-98-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₁₃BrO₂
      Chemical formulaC₁₆H₁₃BrO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCalcium-independent phospholipase A2 (PLA2)
      Primary Target IC<sub>50</sub>60 nM against PLA2
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsReconstitute in chloroform, aliquot into single-use volumes, and dry under inert gas. Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      374085 0

      Documentation

      HELSS Certificates of Analysis

      TitleLot Number
      374085

      References

      Reference overview
      Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
      Lehman, J.J., et al. 1993. J. Biol. Chem. 268, 20713.
      Ramanadham, S., et al. 1993. Biochemistry 32, 337.
      Hazen, S.L., et al. 1991. J. Biol. Chem. 266, 7227.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2008 RFH
      SynonymsBEL, E-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one, Haloenol lactone suicide substrate
      DescriptionA potent, irreversible inhibitor of calcium-independent phospholipase A2 (PLA2, IC50 = 60 nM). Exhibits a 1000-fold higher selectivity for calcium-independent PLA2 versus calcium-dependent PLA2. Inhibits the release of prostaglandin E2 and suppresses the glucose-stimulated release of insulin from pancreatic β-cells.
      FormWhite solid
      CAS number88070-98-8
      Chemical formulaC₁₆H₁₃BrO₂
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml), Ethenol, or Chloroform (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsReconstitute in chloroform, aliquot into single-use volumes, and dry under inert gas. Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAckermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
      Lehman, J.J., et al. 1993. J. Biol. Chem. 268, 20713.
      Ramanadham, S., et al. 1993. Biochemistry 32, 337.
      Hazen, S.L., et al. 1991. J. Biol. Chem. 266, 7227.