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IL017 Interleukin-6 Protein, Recombinant mouse

The recombinant mouse Interleukin-6 protein (or IL-6 protein) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes & hybridoma cells.

Interleukin-6 Protein, Recombinant mouse MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P05231, P08505
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IL017
10 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesPurity
      CULTMouse Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of mouse IL-6.
      Description
      Catalogue NumberIL017
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-6 Protein, Recombinant mouse
      OverviewInterleukin-6 (IL-6) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells. Mouse IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
      Alternate Names
      • IL-6
      References
      Product Information
      PresentationSterile filtered, and then lyophilized with no additives.
      Quality LevelMQ100
      Applications
      ApplicationThe recombinant mouse Interleukin-6 protein (or IL-6 protein) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes & hybridoma cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, mouse IL-6 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): B-cells, hybridoma cells.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of mouse IL-6.
      Specific ActivityThe ED(50) was determined by the dose-dependent stimulation of the proliferation of IL-6 dependent mouse 7TD1 cells is <= 0.02 ng/mL, corresponding to a specific activity of >=5 x 10(E8) units/mg.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
      SIZE: 212 amino acids; 23718 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: N- and O-glycosylated.
      DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
      SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder is stable for a few weeks at room temperature, but best stored at -20ºC for up to 12 months after date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for one week or -20°C for future use. Reconstituted mouse IL-6 should be stored in undiluted aliquots at -20°C for up to 6 months.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      IL017 04053252275432

      Documentation

      Interleukin-6 Protein, Recombinant mouse SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-6 Protein, Recombinant mouse Certificates of Analysis

      TitleLot Number
      /RECOMBINANT MOUSE INTERLEUKIN-6_2843087 2843087
      RECOMBINANT MOUSE INTERLEUKIN-6 2945832
      RECOMBINANT MOUSE INTERLEUKIN-6 2919161
      RECOMBINANT MOUSE INTERLEUKIN-6 3036934
      RECOMBINANT MOUSE INTERLEUKIN-6 2462766
      RECOMBINANT MOUSE INTERLEUKIN-6 - 2332497 2332497
      RECOMBINANT MOUSE INTERLEUKIN-6 - 2061626 2061626
      RECOMBINANT MOUSE INTERLEUKIN-6 - 2064688 2064688
      RECOMBINANT MOUSE INTERLEUKIN-6 - 2091674 2091674
      RECOMBINANT MOUSE INTERLEUKIN-6 - 2159627 2159627
      Show more

      Data Sheet

      Title
      RECOMBINANT MOUSE INTERLEUKIN-6

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