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05-23-0310 Natriuretic Peptide, C-Type, Human and Porcine - CAS 127869-51-6 - Calbiochem

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CNP, GLSKGCFGLKLDRIGSMSGLGC

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05-23-0310
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
127869-51-6C₉₃H₁₅₇N₂₇O₂₈S₃

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05-23-0310-0.5MG
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      05-23-0310-1MG
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          Description
          OverviewMember of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth. Inhibits adenylate cyclase activity in a concentration-dependent manner. Stimulates particulate guanylate cyclase activity. Shown to exert neuromodulatory effects independently of guanylate cyclase activation or adenylate cyclase inhibition.
          Catalogue Number05-23-0310
          Brand Family Calbiochem®
          SynonymsCNP, GLSKGCFGLKLDRIGSMSGLGC
          References
          ReferencesKelley, T., et al. 1997. Am. J. Respir. Cell. Mol. Biol. 16, 464; Inoue, A., et al. 1996. Biochem. Biophys. Res. Commun. 221, 703; Savoie, P., et al. 1995. FEBS Lett. 370, 6; Trachte, G.J., et al. 1995. Am. J. Physiol. 268, C978; Koller, K.J., et al. 1991. Science 252, 120; Sudoh, T., et al. 1990. Biochem. Biophys. Res. Commun. 168, 863.
          Product Information
          CAS number127869-51-6
          ATP CompetitiveN
          FormWhite to off-white lyophilized solid
          FormulationSold on the basis of peptide content.
          Hill FormulaC₉₃H₁₅₇N₂₇O₂₈S₃
          Chemical formulaC₉₃H₁₅₇N₂₇O₂₈S₃
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAdenylate cyclase, particulate guanylate cyclase
          Purity≥96% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Gly-Leu-Ser-Lys-Gly-Cys⁶-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys²²-OH (disulfide bond: 6 → 22)]
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          05-23-0310-0.5MG 04055977206968
          05-23-0310-1MG 04055977206975

          Documentation

          Required Licenses

          Title
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Natriuretic Peptide, C-Type, Human and Porcine - CAS 127869-51-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Natriuretic Peptide, C-Type, Human and Porcine - CAS 127869-51-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          05-23-0310

          References

          Reference overview
          Kelley, T., et al. 1997. Am. J. Respir. Cell. Mol. Biol. 16, 464; Inoue, A., et al. 1996. Biochem. Biophys. Res. Commun. 221, 703; Savoie, P., et al. 1995. FEBS Lett. 370, 6; Trachte, G.J., et al. 1995. Am. J. Physiol. 268, C978; Koller, K.J., et al. 1991. Science 252, 120; Sudoh, T., et al. 1990. Biochem. Biophys. Res. Commun. 168, 863.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-September-2008 RFH
          SynonymsCNP, GLSKGCFGLKLDRIGSMSGLGC
          DescriptionMember of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone and vascular growth. Inhibits adenylate cyclase activity in a concentration-dependent manner. Stimulates particulate guanylate cyclase activity. Shown to exert neuromodulatory effects independent of guanylate cyclase activation or adenylate cyclase inhibition.
          FormWhite to off-white lyophilized solid
          FormulationSold on the basis of peptide content.
          CAS number127869-51-6
          Chemical formulaC₉₃H₁₅₇N₂₇O₂₈S₃
          Peptide SequenceH-Gly-Leu-Ser-Lys-Gly-Cys⁶-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys²²-OH (disulfide bond: 6 → 22)]
          Purity≥96% by HPLC
          Solubility5% acetic acid (1 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesKelley, T., et al. 1997. Am. J. Respir. Cell. Mol. Biol. 16, 464; Inoue, A., et al. 1996. Biochem. Biophys. Res. Commun. 221, 703; Savoie, P., et al. 1995. FEBS Lett. 370, 6; Trachte, G.J., et al. 1995. Am. J. Physiol. 268, C978; Koller, K.J., et al. 1991. Science 252, 120; Sudoh, T., et al. 1990. Biochem. Biophys. Res. Commun. 168, 863.