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513040 PD 174265 - CAS 216163-53-0 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 450 pM).

PD 174265 - CAS 216163-53-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline

Primary Target: EGFR tyrosine kinase activity
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513040
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
216163-53-0C₁₇H₁₅BrN₄O

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513040-1MG
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      Description
      OverviewA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
      Catalogue Number513040
      Brand Family Calbiochem®
      Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
      References
      ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
      Product Information
      CAS number216163-53-0
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₅BrN₄O
      Chemical formulaC₁₇H₁₅BrN₄O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR tyrosine kinase activity
      Primary Target IC<sub>50</sub>450 pM against EGF receptor (EGFR) tyrosine kinase activity
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      513040-1MG 04055977198669

      Documentation

      PD 174265 - CAS 216163-53-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PD 174265 - CAS 216163-53-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      513040

      References

      Reference overview
      Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-February-2012 RFH
      Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
      DescriptionA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.45 nM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number216163-53-0
      Chemical formulaC₁₇H₁₅BrN₄O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.