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516354 Pentoxifylline

A non-selective phosphodiesterase inhibitor.

Pentoxifylline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX

Primary Target: endo toxin-induced synthesis of TNF-α
516354
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      6493-05-6C₁₃H₁₈N₄O₃
      Description
      Overview

      This product has been discontinued.





      A non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-α (TNF-α). PTX inhibits the adhesion of T cells to the β1 and β2 integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal cytochrome P450 caused by lipopolysaccharides.
      Catalogue Number516354
      Brand Family Calbiochem®
      Synonyms3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX
      References
      ReferencesGonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
      Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
      Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
      Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
      Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.
      Product Information
      CAS number6493-05-6
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₃H₁₈N₄O₃
      Chemical formulaC₁₃H₁₈N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetendo toxin-induced synthesis of TNF-α
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXH2475000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      516354 0

      Documentation

      Pentoxifylline SDS

      Title

      Safety Data Sheet (SDS) 

      Pentoxifylline Certificates of Analysis

      TitleLot Number
      516354

      References

      Reference overview
      Gonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
      Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
      Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
      Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
      Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2009 RFH
      Synonyms3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX
      DescriptionA non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-α (TNF-α). PTX inhibits the adhesion of T cells to the β1 and β2 integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal P450 caused by lipopolysaccharides.
      FormWhite crystalline solid
      CAS number6493-05-6
      RTECSXH2475000
      Chemical formulaC₁₃H₁₈N₄O₃
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 7136
      ReferencesGonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
      Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
      Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
      Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
      Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.