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559270 Rb/Raf-1 Disruptor 251

A cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction, while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/HDAC1, Raf-1/MEK1.

Rb/Raf-1 Disruptor 251 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: S-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      72214-67-6C₈H₉Cl₃N₂S
      Description
      OverviewA cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction (IC50 = 77 nM in cell-free binding assays), while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/prohibitin, Rb/cyclin E, Rb/HDAC1, Raf-1/MEK1, or Raf-1/MEK2 interaction. Suppresses cellular E2F transcription activity and reduces serum-induced Rb phosphorylation. Shown to display Rb-dependent antitumor activity both in cultures in vitro and in mice in vivo.
      Catalogue Number559270
      Brand Family Calbiochem®
      SynonymsS-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251
      References
      ReferencesKinkade, R., et al. 2008. Cancer Res. 68, 3810.
      Product Information
      CAS number72214-67-6
      FormWhite solid
      Hill FormulaC₈H₉Cl₃N₂S
      Chemical formulaC₈H₉Cl₃N₂S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. However, it is strongly recommended that stock solutions be prepared fresh just prior to each use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      559270 0

      Documentation

      Rb/Raf-1 Disruptor 251 SDS

      Title

      Safety Data Sheet (SDS) 

      Rb/Raf-1 Disruptor 251 Certificates of Analysis

      TitleLot Number
      559270

      References

      Reference overview
      Kinkade, R., et al. 2008. Cancer Res. 68, 3810.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsS-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251
      DescriptionA cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction (IC50 = 77 nM in cell-free binding assays), while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/prohibitin, Rb/cyclin E, Rb/HDAC1, Raf-1/MEK1, or Raf-1/MEK2 interaction. Suppresses cellular E2F transcription activity and reduces serum-induced Rb phosphorylation. Shown to display Rb-dependent antitumor activity both in cultures in vitro and in mice in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number72214-67-6
      Chemical formulaC₈H₉Cl₃N₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. However, it is strongly recommended that stock solutions be prepared fresh just prior to each use.
      Toxicity Irritant
      ReferencesKinkade, R., et al. 2008. Cancer Res. 68, 3810.