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573080 STAT1 Enhancer, 2-NP - CAS 65182-56-1 - Calbiochem

A cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-NP, 2-(1,8-Naphthyridin-2-yl)phenol

Primary Target: Selectively enhances cytokine-induced STAT1 transcription activity
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      65182-56-1C₁₄H₁₀N₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB. Shown to prolong INF-γ-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.
      Catalogue Number573080
      Brand Family Calbiochem®
      Synonyms2-NP, 2-(1,8-Naphthyridin-2-yl)phenol
      References
      ReferencesLynch, R. A., et al. 2007. Cancer Res. 67, 1254.
      Product Information
      CAS number65182-56-1
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₄H₁₀N₂O
      Chemical formulaC₁₄H₁₀N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetSelectively enhances cytokine-induced STAT1 transcription activity
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      573080 0

      Documentation

      STAT1 Enhancer, 2-NP - CAS 65182-56-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Lynch, R. A., et al. 2007. Cancer Res. 67, 1254.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms2-NP, 2-(1,8-Naphthyridin-2-yl)phenol
      DescriptionA cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB. Shown to prolong INF-γ-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number65182-56-1
      Chemical formulaC₁₄H₁₀N₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesLynch, R. A., et al. 2007. Cancer Res. 67, 1254.