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178281 p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem

Alternative to DFP and PMSF.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: p-Amidinophenylmethylsulfonylfluoride, HCl

Primary Target: trypsin-like serine proteases
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178281
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Overview

Replacement Information

Key Spec Table

CAS #
74938-88-8

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      Description
      OverviewAlternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
      Catalogue Number178281
      Brand Family Calbiochem®
      Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
      References
      ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
      Laura, R., et al. 1980. Biochemistry 19, 4859.
      Product Information
      CAS number74938-88-8
      ATP CompetitiveN
      FormWhite solid
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targettrypsin-like serine proteases
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      178281-5MG 04055977222432

      Documentation

      p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      178281

      References

      Reference overview
      Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
      Laura, R., et al. 1980. Biochemistry 19, 4859.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
      DescriptionAn alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.
      FormWhite solid
      CAS number74938-88-8
      Purity≥97% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
      Laura, R., et al. 1980. Biochemistry 19, 4859.