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Merck

12072

Benzamidine

≥95.0%

Synonym(s):

Benzenylamidine, Phenylamidine

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About This Item

Linear Formula:
C6H5C(=NH)NH2
CAS Number:
618-39-3
Molecular Weight:
120.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57646968
EC Number:
210-546-3
Beilstein/REAXYS Number:
606020
MDL number:
MFCD00042826
Assay:
≥95.0%
Form:
powder or crystals

Key Documents

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InChI key

PXXJHWLDUBFPOL-UHFFFAOYSA-N

InChI

1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)

SMILES string

NC(=N)c1ccccc1

assay

≥95.0%

form

powder or crystals

functional group

amine, phenyl

Quality Level

200

Gene Information

human ... F10(2159), F2(2147), PLAT(5327), PLAU(5328), PLG(5340), PRSS1(5644)

Related Categories

Application

Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor).

Biochem/physiol Actions

Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH.

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H315

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

12072-BULK: + 12072-10G: + 12072-50G: + 12072-INTR: + 12072-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ0849
BCCB9118
BCBT9196
BCBL7181V
BCBF3350V

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Purification and characterization of bovine coagulation factor XII (Hageman factor).
H Claeys et al.
European journal of biochemistry, 87(1), 69-74 (1978-06-01)
Hung-Wei Chang et al.
PLoS pathogens, 15(6), e1007826-e1007826 (2019-06-21)
Vaccinia mature virus requires A26 envelope protein to mediate acid-dependent endocytosis into HeLa cells in which we hypothesized that A26 protein functions as an acid-sensitive membrane fusion suppressor. Here, we provide evidence showing that N-terminal domain (aa1-75) of A26 protein
Ana L Roa-Espitia et al.
Biology open, 5(9), 1189-1199 (2016-07-13)
Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed. However, how these proteins function
Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma.
J W Ensinck et al.
The Journal of clinical endocrinology and metabolism, 35(3), 463-467 (1972-09-01)
Yubing Li et al.
eLife, 5, e10767-e10767 (2016-03-26)
Proliferating cells actively control their size by mechanisms that are poorly understood. The unicellular green alga Chlamydomonas reinhardtii divides by multiple fission, wherein a 'counting' mechanism couples mother cell-size to cell division number allowing production of uniform-sized daughters. We identified
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