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900188

Poly(N-isopropyl acrylamide)

NHS ester end functionalized, average Mn 5,000

Synonym(s):

PNIPAM, polyNIPAM

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About This Item

Linear Formula:
C8H10NO4(C6H11NO)nH
NACRES:
NA.23
UNSPSC Code:
12162002
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Quality Level

100

form

solid

mol wt

average Mn 5,000

storage temp.

2-8°C

Application

Poly(N-isopropyl acrylamide) (PolyNIPAM) is a stimuli-responsive polymer. This product features low polydispersity (PDI), which typically leads to better reproducibility in applications, and a terminal N-hydroxysuccinimide (NHS) functional group, allowing for rapid conjugation of biomolecules, small molecules, or other polymers. PolyNIPAM has been used in development of a variety of thermosensitive coated micro/nano materials, including thermoresponsive polymeric drug delivery systems.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

900188-1G: + 900188-BULK: + 900188-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF6554

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Articles

Smart Nanofiber Meshes as a Local Drug Delivery Platform

Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.

体内移植型局所薬物送達プラットフォームとしてのスマートナノファイバーメッシュ

ナノファイバーとスマートポリマーと組み合わせた「スマートナノファイバー」は外部刺激を与えることでその性質を劇的に遠隔制御が可能であるため、医療分野のみならず様々な分野で期待が寄せられています。薬剤放出の制御とハイパーサーミアへの応用について解説いただきました。

Yan Xia et al.
Chemical communications (Cambridge, England), 49(25), 2566-2568 (2013-02-21)
Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates.
Aniket S Wadajkar et al.
Acta biomaterialia, 8(8), 2996-3004 (2012-05-09)
New magnetic-based core-shell particles (MBCSPs) were developed to target skin cancer cells while delivering chemotherapeutic drugs in a controlled fashion. MBCSPs consist of a thermo-responsive shell of poly(N-isopropylacrylamide-acrylamide-allylamine) and a core of poly(lactic-co-glycolic acid) (PLGA) embedded with magnetite nanoparticles. To
Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
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