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Merck

05-170

Anti-IL-2 Rα Antibody, clone 7G7/B6

clone 7G7/B6, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
7G7/B6, monoclonal
Application:
DB, ICC
Citations:
22

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7G7/B6, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

dot blot: suitable, immunocytochemistry: suitable

isotype

IgG2a

NCBI accession no.

NM_000417.1

UniProt accession no.

P01589

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... IL2RA(3559)

General description

55 kDa

Immunogen

Whole cells expressing human IL-2 Receptor α

Application

Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
This Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.

Biochem/physiol Actions

Recognizes interleukin-2 receptor.

Physical form

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.

Preparation Note

Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C

Analysis Note

Control
Lung tissue
routinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Poisonous substance

pdsc

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

05-170:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac.
Rubin, L A, et al.
Hybridoma, 4, 91-102 (1985)
Benjamin C Jennings et al.
FEBS letters, 595(13), 1758-1767 (2021-05-16)
The SARS-CoV-2 spike glycoprotein (spike) mediates viral entry by binding ACE2 receptors on host cell surfaces. Spike glycan processing and cleavage, which occur in the Golgi network, are important for fusion at the plasma membrane, promoting both virion infectivity and
P D Tahiliani et al.
The Journal of biological chemistry, 272(12), 7892-7898 (1997-03-21)
Integrin-mediated adhesion of cells to extracellular matrix proteins triggers a variety of intracellular signaling pathways including a cascade of tyrosine phosphorylations. In many cell types, the cytoplasmic focal adhesion tyrosine kinase, FAK, appears to be the initial protein that becomes
K S Lai et al.
The Journal of biological chemistry, 270(42), 25028-25036 (1995-10-20)
Signal transduction of cytokine receptors is mediated by the JAK family of tyrosine kinases. Recently, the kinase partners for the interleukin (IL)-2 receptor have been identified as JAK1 and JAK3. In this study, we report the identification of splice variants
Sabine S Lange et al.
PLoS genetics, 12(1), e1005759-e1005759 (2016-01-05)
DNA polymerase ζ (pol ζ) is exceptionally important for maintaining genome stability. Inactivation of the Rev3l gene encoding the polymerase catalytic subunit causes a high frequency of chromosomal breaks, followed by lethality in mouse embryos and in primary cells. Yet
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Global Trade Item Number

SKUGTIN
05-17004053252323386

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