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Merck

07-631

Anti-cdk2 Antibody

Upstate®, from rabbit

Synonym(s):

Anti-CDKN2, Anti-p33(CDK2)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human
Application:
IP, WB
Citations:
18

Key Documents

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antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_001798

UniProt accession no.

P24941

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CDK2AP1(8099)

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

Related Categories

General description

33 kDa

Immunogen

peptide corresponding to amino acids 287-298 (C-QDVTKPVPHLRL) of human cdk2

Application

Anti-cdk2 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of cdk2 & has been validated in IP & WB.

Biochem/physiol Actions

Predicted to cross-react with mouse, rat, non-human primates, and hamster based on sequence homology
Recognizes human p33cdk2 protein kinase.

Physical form

Format: Purified

Analysis Note

Control
Colon tissue
routinely evaluated by immunoblot in nuclear extracts from HeLa cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

07-631:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carlotta Costa et al.
Cancer discovery, 10(1), 72-85 (2019-10-09)
The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patients treated with the combination of the CDK4/6 inhibitor
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Elledge, S J, et al.
Proceedings of the National Academy of Sciences of the USA, 89, 2907-2911 (1992)
Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.
Restle, A; Farber, M; Baumann, C; Bohringer, M; Scheidtmann, KH; Muller-Tidow, C; Wiesmuller, L
Nucleic Acids Research null
S J Elledge et al.
The EMBO journal, 10(9), 2653-2659 (1991-09-01)
The onset of S-phase and M-phase in both Schizosaccharomyces pombe and Saccharomyces cerevisiae requires the function of the cdc2/CDC28 gene product, p34, a serine-threonine protein kinase. A human homolog, p34cdc2, was identified by functional complementation of the S.pombe cdc2 mutation
Sublytic complement attack induces cell cycle in oligodendrocytes.
Rus, H G, et al.
Journal of immunology (Baltimore, Md. : 1950), 156, 4892-4900 (1996)
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Global Trade Item Number

SKUGTIN
07-63104053252369995

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