12666
Albumin, Human Serum, Fraction V, Low Heavy Metals
Synonym(s):
Albumin, Human Serum, Fraction V, Low Heavy Metals
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About This Item
Assay:
≥95% (SDS-PAGE)
Form:
solid
Impurities:
≤5.0% Ash, ≤6% moisture
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
description
Merck USA index - 14, 8468
assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤5.0% Ash, ≤6% moisture
pI
4.7
solubility
water: 50 mg/mL
cation traces
heavy metals: ≤20 ppm
shipped in
ambient
Quality Level
General description
Human serum albumin (HSA) is an abundant protein found in the plasma. This globular, soluble, and unglycosylated monomeric protein, has three homologous domains (I, II, and III). These domains have subdomains A and B having common structural motifs. The HSA gene is located on the human chromosome 4q13.3.
Application
Albumin, Human Serum, Fraction V, Low Heavy Metals has been used:
- as a supplement in double buffer and milliQ-water for in vivo
- in serum-free media for polarized secretion assays in human dermal microvascular endothelial cells
- as a supplement in sodium phosphate buffer for the reconstitution of hormone lysis samples
Biochem/physiol Actions
Human serum albumin (HSA) is very crucial in stabilizing extracellular fluid volume. It functions as an excipient for vaccines and therapeutic protein drugs. HSA serves as a cell culture medium supplement for the synthesis of vaccines and pharmaceuticals. It is useful as a carrier protein for steroids, fatty acids, and thyroid hormones. HSA is used to treat cardiopulmonary bypass, trauma, hemorrhage, and hypoalbuminemia. HSA is useful in biological applications, such as implantable biomaterials, biochromatography, surgical adhesives, and sealants.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Tina Jorsal et al.
The Journal of clinical endocrinology and metabolism, 104(12), 6403-6416 (2019-07-06)
After Roux-en-Y gastric bypass (RYGB) surgery, postprandial plasma glucagon concentrations have been reported to increase. This occurs despite concomitant improved glucose tolerance and increased circulating plasma concentrations of insulin and the glucagon-inhibiting hormone glucagon-like peptide 1 (GLP-1). To investigate whether
C J Kelley et al.
Microbiology spectrum, 10(6), e0360122-e0360122 (2022-11-08)
As multidrug and pan-resistance among Enterobacterales continue to increase, there is an urgent need for more therapeutic options to treat these infections. New β-lactam and β-lactam inhibitor (BLI) combinations have a broad spectrum of activity, but those currently approved do
Stephan Schmidt et al.
Antimicrobial agents and chemotherapy, 52(11), 3994-4000 (2008-09-10)
During antibiotic drug development, media are frequently spiked with either serum/plasma or protein supplements to evaluate the effect of protein binding. Usually, previously reported serum or plasma protein binding values are applied in the analysis. The aim of this study
Chanchal Sadhu et al.
Journal of immunology (Baltimore, Md. : 1950), 170(5), 2647-2654 (2003-02-21)
Neutrophil chemotaxis is a critical component of the innate immune response. Neutrophils can sense an extremely shallow gradient of chemoattractants and produce relatively robust chemotactic behavior. This directional migration requires cell polarization with actin polymerization occurring predominantly in the leading
Nicolai J Wewer Albrechtsen et al.
American journal of physiology. Endocrinology and metabolism, 311(2), E302-E309 (2016-06-02)
Glucagon is a metabolically important hormone, but many aspects of its physiology remain obscure, because glucagon secretion is difficult to measure in mice and rats due to methodological inadequacies. Here, we introduce and validate a low-volume, enzyme-linked immunosorbent glucagon assay
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 12666-100GMCN | 04055977222807 |
| 12666-10GMCN | 04055977222791 |
| 12666-1GMCN | 04055977222777 |
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