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Merck

14-595-M

PP1α Protein, 10 µg

Recombinant, full length, human PP1α, for use in Phosphatase Assays.

Synonym(s):

PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32
eCl@ss:
32160405
Form:
solution
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
Mw 37.6 kDa

Key Documents

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Product Name

PP1α Protein, 10 µg, Recombinant, full length, human PP1α, for use in Phosphatase Assays.

biological source

human

recombinant

expressed in E. coli

form

solution

shelf life

6 mo.

mol wt

Mw 37.6 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (phosphatase)

solubility

water: soluble

NCBI accession no.

NM_001008709.1
NM_002708.3
NM_206873.1

UniProt accession no.

P62136

storage temp.

−20°C

Quality Level

100

Gene Information

human ... PPP1CA(5499)

Analysis Note

routinely evaluated by dephosphorylation of 100μM DiFMUP

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase

Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.

Physical form

Heparin agarose followed by Q agarose

Preparation Note

6 months at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

14-595M: + 14-595:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson?s disease
Braithwaite SP, et al.
Neurochemistry International, 61, 899-906 (2012)
Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
14-595M04053252734519
14-59504053252471650

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